Targeting HIF2α in Clear-Cell Renal Cell Carcinoma.
نویسندگان
چکیده
In two recent studies, the HIF2α antagonist, PT2399, decreased HIF2α-dependent transcription and tumor growth in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models. These studies validate HIF2α as a therapeutic target in ccRCC, reveal variable sensitivity to HIF2α antagonism, and provide the foundation for predictive biomarker-driven clinical trials.
منابع مشابه
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ورودعنوان ژورنال:
- Cancer cell
دوره 30 4 شماره
صفحات -
تاریخ انتشار 2016